• Issue - Can't launch game using default 64-bit, only works in 32-bit
• Platform - Windows 10
  • Version    10.0.19042 Build 19042
• Specs - 
  • 2 x 2560 x 1440 (144hz) monitors - DP
  • EVGA RTX 3080
  • intel i5 11600k
  • 2tb m.2 ssd
  • 16 GB 3200MHz RAM
• Version - Latest, can't load menu to check
• Output_log.txt + Diagnostics.html 
  • drive-download-20210509T045516Z-001.zip
• Registry.xml - I've tried with deleting the registry.xml and getting default, contents are currently:
  • <?xml version="1.0" encoding="utf-8"?>

    <Registry xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema">

      <Settings>

        <AutoSave>

          <MaximumNumberOfAutoSaveFiles>4</MaximumNumberOfAutoSaveFiles>

        </AutoSave>

        <Diagnostics>

          <MaximumNumberOfDiagnosticsFiles>4</MaximumNumberOfDiagnosticsFiles>

        </Diagnostics>

        <Steam>

          <CloudRemoteStorage>False</CloudRemoteStorage>

        </Steam>

        <Video>

          <Fullscreen>False</Fullscreen>

          <HighDefinitionUI>False</HighDefinitionUI>

          <Palette>FactionColors</Palette>

          <Resolution>1280x720</Resolution>

        </Video>

      </Settings>

      <Preferences>

        <Lobby>

          <Faction>MadFairies</Faction>

        </Lobby>

      </Preferences>

      <Legal>

        <RunOnce>

          <AlphaDisclaimerAcknowledged>False</AlphaDisclaimerAcknowledged>

        </RunOnce>

      </Legal>

      <Miscellaneous>

        <UnitBodyInspectorWindow>

          <ShaderProperties>_MainTex:Diffuse texture,_BumpMap:Normal map,_SpecMap:Gloss color map,_IlluminMap:[Self] Illumination map,_FactionMaskMap:Faction mask map,_FireMaskMap,_FireGrandiantMap,_WaterTex</ShaderProperties>

        </UnitBodyInspectorWindow>

      </Miscellaneous>

    </Registry>

1. changing resolution at startup 
2. Latest GPU drivers
3. Update Mobo BIOS
4. Update Windows
5. Uninstalled and reinstalled the game from Steam
6. Latest .NET Framework
7. Tried running in administrator mode
8. Tried forcing DX11
9. Only running with 1 monitor attached
10. Disabling precision x1
11. Disabling Nvidia in-game overlay
12. Disabling all mods
13. Running in 32-bit mode and making sure all settings work
14. Deleting all cloud content
15. Starting windowed
16. Launching in compatibility mode
17. Probably more...

No real clue about your issue on my end. But as long as you tried a lot fixes, perhaps to download and (re-) install Mono net.framework is worth a shot.

Mono

Edit: You also could try to download and install K-Lite mega codeq pack.