I agree, the -10% SCI throughout the Empire seems like too much of a penalty to justify building it in most situations. Although when I actually tested it out, I think I still got a decent net increase in Science from it, so that probably isn't the right complaint... (Also, apparently there isn't actually a -10% to the rest of the Empire applied.)

Rather, I would complain it's too hard to calculate whether it's an overall bonus or penalty, so we're tempted to just avoid building it. I would recommend using this instead:

• 10% of Science from all other systems in Empire is transferred to this system instead (to symbolize scientists gathering in a center of learning)
• +X% bonus to all Science in this system (including the transferred Science)

That way, you never have a situation where building the Intergalactic Technology Center actually hurts your science production.