Well if it did not, then it most likely can not and will not. =/
There is no direct user control over trade routes and they are always picking the shortest path.

Let me add some pictures.

As you see, I have company headquarters in Nar Idis, Nar Likim and Masitam. My trade route needs to pass through Zhaen.

But even though Ybela is now closed, I see no blockaded routes in the economy screen.

This situation actually makes me happy, but I wonder, if Ybela is closed, where are my trade routes passing through?

well you can always call up the "space" eco screen