Your Output log does seem to end abruptly,

Normaly Just after: (Filename:  Line: 447) 

you get something like this: (this is only the first few lines)

Gamesight: Setting verbose logs to True
(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/DebugBindings.gen.cpp Line: 51)
Gamesight: Setting API key to 0fe715eaaaac8b4b62fa124a7031b7f1
(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/DebugBindings.gen.cpp Line: 51)
Gamesight: Setting User ID to [steamID64]
(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/DebugBindings.gen.cpp Line: 51)
Gamesight: Marking conversion
(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/DebugBindings.gen.cpp Line: 51)

Platform assembly: [%Install Folder%]Endless Space 2\EndlessSpace2_Data\Managed\System.Data.dll (this message is harmless)
Game Session-Open: {"crc":"EDA9CA89669364DFD59EC0F7EA1BF430,206760","hwid":"263ea31387b68158515bdc840e3511d9200c5127","system_os":"Windows 10  (10.0.0) 64bit","system_processor":"Intel(R) Core(TM) i7-4790 CPU @ 3.60GHz","system_memory":"8529117184","system_display":"NVIDIA GeForce GTX 750 Ti","system_display_memory":"2114977792","eventID":"1.21.01","eventName":"Game Session-Open","steamID":"[steamID64]","gamecode":"392110","sessionID":"878cae1de83a4f859bd571ab6a1b8735","eventTimestampClient":"[Time & Date]"}

(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/DebugBindings.gen.cpp Line: 51)

Gamesight: Event created! Reponse: {
"event": {
"created_at": "[Time & Date]",
"id": [Game ID]
"identifiers": {
"installed_browsers": null,
"installed_fonts": null,
"language": null,
"os": "Windows 10  (10.0.0) 64bit",
"resolution": "1920x1080",
"timezone": null
},
"ip": "[Your IP]",
"type": "game_launch",
"user_id": "[steamID64]",
"version": "1.0.0"
}
}

[...]

The bit you have after: (Filename:  Line: 447) is normaly found at the very end of all output_logs, so it appears that (Filename:  Line: 447) is the point at which something is going wrong.

I must admit, I'm not a dev and I do not know what it is that is going wrong, I just thought that I would let you know that there is an anomaly with your output_log and so the devs may be able to provide insight into what is going wrong for you.

Thanks, I'll send one of them a message!

Hy ZumboPrime!

That really looks like a hardware issue ...
Did you try to start another game to see if you had the same problem? 

Did you update all the drivers for your new configuration?

My other games were all working fine. I did end up doing the reinstall of the OS and it's working now. Probably hardware drivers conflicting as you suggested.

Closing this as fixed.