I tend to play the game without economic and sciene based victories, and I have some friends who play in a similar fashion. One thing I have thought about is having some kind of improvement that allows you to convert left over science production to be converted into dust, food, influence, or production. Because right now, if you research everything, science becomes useless. Food is solved with the improvement that converts it into production, but there is no such thing for science which I think could be a good idea if you play a game where you are done reasearching by turn 200 on nomral speed as the Sophons.