Had this happen on the same map today.
Should probably flag this up as a major bug as it has the potential to completely softlock a run if you're unlucky enough to have a missing floor prevent access to the critical path forward.
Happened to me during area transition, blocking progress.
Here's some video footage of the bug:
https://www.youtube.com/watch?v=JtwBY6VZONw
Had the same thing happen to me, was going for Zed's quest and had a decent run going but locked down by this room layout.
https://steamcommunity.com/id/Mogul162/screenshot/2124069045062373955/
Reported on Steam too (https://steamcommunity.com/app/1485590/discussions/2/3877095689964961609/)
Hive Mind_90 HM01_DL_02_01_LEFT -758762956 => "There was a literal hole in the floor, and we couldn't progress."
New Steam report with Seed:
I've encountered the same issue here (not the first time). I'm playing solo, and when I open a door, everyone, including enemies, gets stuck. They can only move when I'm within range to touch them. I've tried shutting down the game and launching it a couple of times, but the same room keeps blocking my progress. I managed to avoid the door bug in my previous run (as it was not mandatory to open it before), but I can't do that this time.
Here's the game seed: Chambre forte_90 SV01_DL_02_01_FWD 821622852. I can send you a short video if needed to demonstrate the issue.
Floor was see-through on a level, completely blocking off the last door I needed to reach completely killing the run.
Happened in the Procedural Factory for me.