The difference between fastest and prettiest is pretty minimal, tbh. My computer sucks, yes, but it is able to get 30 fps in TTW:W2 and Civ 6 no problem. Meanwhile, Humankind gets stuck at about 10, dropping to 5 in the late game 

I know that with Unreal games you can reduce Scaling Resolution in /appdata/, can you do the same on Unity or perhaps somewhere in Humankind files?