I have this doubt. Is it better to create cities focused on a type of district, turning it into a mega city in a type of resource, or go creating districts as demand? I feel that making a city that has "everything" makes it not good at anything, but I'm not sure about that.
If you're asking about what type of districts to build, then it's going to be heavily dependent on your situation - this means the environment around your city (what FIMS it's heavy on), your culture (and future cultures) and whatever you seem to be lacking.
Generally speaking, my priority is this:
1) Emblematic quarters. Part of the reason you pick a culture is for its EQ. And you only have a limited time to build it, so build it as soon as you can - though you may want to build other districts to set up a powerful spot for it
2) Production districts - the virtuous spiral. The more of these, the more you can build. You can never have too many (other than being bored)
3) Food if necessary. Usually I want a healthy surplus of food so the population keeps growing.
4) Market/Science/Commons - I rarely build unless I'm absolutely behind on gold (need money to upgrade units) or science (need to get better units) OR my culture makes some powerful bonus with them. Usually though, my culture picks will give me enough of these through the EQ.
If you are asking about what layout of the districts - I'm not good at this, so someone else can answer.
If you play efficiently you'll usually end up with cities that all look mostly the same unfortunately. Some might be a little more money focused and some(most) more science focused just because of the adjacency favoring bunching all the same quarters together but specialization doesn't lead to anything spectacular.
The first problem is that every city has to be a production city to get decent yield of any kind.
The second problem is that a lot of your yield comes from emblematic quarters and legacy traits, therefore a large proportion of your yields come from your culture choices which impact all your cities. If you only pick science civs all your cities will end up producing a lot of science, and if you pick merchant civs they will produce a lot of money. You are usually also incentivized to get adjacency with your emblematics but this just means you are even less incentivized to specialize since every territory only has 1 instance of each and only so many districts can be adjacent to it.
The 3rd problem is that buildings which amplify your yield are dirt cheap for a production focused city( in the current meta this should be every city) and don't have a maintenance cost so you can easily just have every building in every city, this is further amplified by the settler unit which just straight up creates cities with all buildings.
It's good to specialize, specifically to save on infrastructure time (getting all of those science upgrades takes time and isnt worth it if you aren't focusing on science). Every city needs a certain amount of food and production, but having a city that's more production focused than others lets you dedicate it to building armies or working on wonders. In a money city you still need a certain amount of maker's quarters, but it's less worth while to build a ton of them because all that production will go towards (should) be making more commerce quarters.
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The best tip i can give you is to make sure at least half of your districts are Makers Quarters and then you just build based on what you have in the territories, aka if you have strategic resources you should build towards them to have science quarters, also there are some tiles that produces science as well. If you are planning do go to war and have a army, you can build market quarters towards luxury resources etc. Another thing i highly suggest is to think a lot about outpost placement, as in before placing your outposts where and how you will build your districts. Sometimes placing the outpost on a slightly worse location is worth it if you can get some really good districts, since early districts are cheap.
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