I agree with this idea ! Lots of interesting Natural Wonder could be derived from this idea and ultimately it would give some other objective than "I want more territory" to a player to incite a war ! 

I would prefer to see more information about wonders and regions before supporting this proposal.

I can understand multi-tile natural wonders, having a region-wide wonder seems troublesome to design and test.

Based on the gameplay reveal, I am happy with the bonuses provided by natural wonders so far. I would like to see an improvement of the "National Park" mechanic from Civ6, to give players more control over the shape and size of natural preserves.

While the idea is interesting, I agree with Aye_Avast, we've been shown only a little fraction of the gameplay.

As you said Rac98, we have no idea of the scale of the map right now, having a Natural Wonder spanning on more than 4 tiles (like the biggest ones on Civ6) could be a "waist" of usable land for the player (either human or AI).

Plus, given what we could see in the gameplay regarding the Natural Wonders bonuses, I'd say that if you had to "share" the bonuses with someone else, that would be a fraction quite small that it wouldn't be interesting. I guess the only viable choice would be to claim the entire territory before your neighbour or declare war on your neighbour to control the territory and get the Natural Wonder bonuses.

While I agree we should see more of how the map works to tell for sure there is still some points I disagree on.

Sure a wonder could become a "waste of space" for players but that depend on gameplay and in the end a good 4x is based on choices that provide you both advantages and disadvantages ! Giving player the opportunity of having Natural Wonders without having to give anything in exchange is for me a really bad choice, it cleave the game between those that are lucky enough to have a good Natural Wonder and those that doesn't. Even if this idea is scrapped and Wonders end up spanning only one region I think the dev shouldn't shy away from pushing player to make a meaningful choice like sacrificing some food or industry to gain some influence thanks to the Wonder !
Beside Humankind is the perfect type of game for this mechanic, sure you could argue that if you spawn in a region where one Wonder take a big chunk of the region you can't play "Tall" and exploit this region to it's full extent, and to that I'd say, well yes, but Humankind is a game about adapting, if you spawn in this type of region just play Aesthete or whatever might synergise well with the Wonder, if you don't like it, reset your map. Humankind is not meant to be the classical 4x game where you have one type of victory in mind as soon as you launch your game, it's the type fo game where you can just make thing up as you go ! 

As for the Wonder exploitation, I think multi-regional wonder shouldn't give bonuses until you control every regions they are a part of, that would give an incentive to take control of those regions. Also the idea that could "work" these Wonder is cool even tho I think it should take maybe a different approach, if we get the German Black Forest for example it would not make sense to exploit it with lumber mill, same can be said for a lot of other Wonders. Therefore a type of exploitation you could have coul be tourism spot or something alike. That being said, ideally those Wonder would have bonuses making them good enough without being exploited

Conclusion : I agree that we should wait and see for now, we're still not sure how the map generation and the Wonders work exactly and we can always add this feature after the base game. That being said I'm very much in favor of adding some opportunities for Aesthete player to gear toward some form of warfare.